Clear-Cell RCC — written by a broken gene

reveal-mode previz · clear cytoplasm & chicken-wire vessels · VHL → HIF → VEGF resolves last · looping
clear-cell renal cell carcinoma histology, clean base
clear cytoplasm — lipid & glycogen
dissolve out in processing,
so the cells look empty
delicate "chicken-wire"
capillary network
small, round,
low-grade nuclei
VHL inactivated
→
HIF-α accumulates
→
VEGF drives this vasculature
one broken tumor-suppressor, painted into the tissue
Clean plate · every ring, label, and the VHL→HIF→VEGF chain re-added on the clock.